Back to Search Results

Endogenous Circulating Sex Hormone Concentrations and Colon Cancer Risk in Postmenopausal Women: A Prospective Study and Meta-Analysis.

Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France. Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden. Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden. Department of Epidemiology and Biostatistics, Imperial College London, Norfolk Place, London, UK. Department of Nutrition, Bjørknes University College, Oslo, Norway. Department of Endocrinology, Morbid Obesity and Preventive Medicine, Oslo University Hospital, Ullevål, Oslo, Norway. Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece. Paris-Saclay University, UVSQ, Inserm, Gustave Roussy, "Exposome and Heredity" team, CESP, Villejuif, France. Department of Statistics, Computer Science, Applications "G. Parenti," University of Florence, Florence, Italy. Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. Department of Molecular Epidemiology, German Institute of Human Nutrition, Potsdam, Germany. Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain. Escuela Andaluza de Salud Pública (EASP), Granada, Spain. Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain. Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain. Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid Spain. Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia. Navarra Public Health Institute, Pamplona, Spain. IdiSNA, Navarra Institute for Health Research, Pamplona, Spain. Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK. Institute for Cancer Research, Prevention and Clinical Network-ISPRO, Florence, Italy. Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy. Cancer Registry and Histopathology Department, Provincial Health Authority (ASP 7), Ragusa, Italy. Unit of Cancer Epidemiology, Piedmont Children Cancer Registry, Città della Salute e della Scienza University-Hospital and Center for Cancer Prevention (CPO), Turin, Italy. Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy. Centre for Nutrition, Prevention and Health Services, National Institute for Public Health and the Environment, Bilthoven, The Netherlands. Faculty of Health Sciences, Department of Community Medicine, UiT The Arctic University of Norway, Tromsø, Norway. Department of Pharmacy, The Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway.

JNCI cancer spectrum. 2021;(6)
Full text from:

Other resources

Abstract

BACKGROUND Observational studies have consistently reported that postmenopausal hormone therapy use is associated with lower colon cancer risk, but epidemiologic studies examining the associations between circulating concentrations of endogenous estrogens and colorectal cancer have reported inconsistent results. METHODS We investigated the associations between circulating concentrations of estrone, estradiol, free estradiol, testosterone, free testosterone, androstenedione, dehydroepiandrosterone (DHEA), progesterone, and sex hormone-binding globulin (SHBG) with colon cancer risk in a nested case-control study of 1028 postmenopausal European women (512 colon cancer cases, 516 matched controls) who were noncurrent users of exogenous hormones at blood collection. Multivariable conditional logistic regression models were used to compute odds ratios and 95% confidence intervals to evaluate the association between circulating sex hormones and colon cancer risk. We also conducted a dose-response meta-analysis of prospective studies of circulating estrone and estradiol with colorectal, colon, and rectal cancer risk in postmenopausal women. All statistical tests were 2-sided. RESULTS In the multivariable model, a nonstatistically significantly positive relationship was found between circulating estrone and colon cancer risk (odds ratio per log2 1-unit increment = 1.17 [95% confidence interval = 1.00 to 1.38]; odds ratioquartile4-quartile1  = 1.33 [95% confidence interval = 0.89 to 1.97], P trend  = .20). Circulating concentrations of estradiol, free estradiol, testosterone, free testosterone, androstenedione, DHEA, progesterone, and SHBG were not associated with colon cancer risk. In the dose-response meta-analysis, no clear evidence of associations were found between circulating estradiol and estrone concentrations with colorectal, colon, and rectal cancer risk. CONCLUSION Our observational and meta-analysis results do not support an association between circulating concentrations of endogenous sex hormones and colon or rectal cancer in postmenopausal women.

Methodological quality

Publication Type : Meta-Analysis ; Multicenter Study

Metadata